Glutaminergic receptors in rostral ventrolateral medulla mediate the cardiovascular responses to activation of bed nucleus of the stria terminalis in female rats

نویسندگان

  • CVR de Oliveira
  • J Ciriello
  • M Ganjkhani
  • M Hatam
چکیده مقاله:

The bed nucleus of the stria terminalis (BST) has been known to contain estrogen (E)-concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of glutamate antagonist receptors in the rostral ventrolateral medulla (RVLM) on the cardiovascular responses to Glu stimulation of BST (0.25 M; 20 nl) was investigated in the chloralose anaesthetized, ovariectomized (OVX; n=6) or OVX+E-treated (30 pg/ml plasma E; n=10) female Wistar rats. Glu stimulation of the BST decreased AP (-15 ± 5 mmHg) and HR (-25.23± 2 bpm) in the OVX+E animals and in OVX only animals (AP, -29.78 ± 4.17 mmHg; HR, -17.3 ± 3.1 bpm). Microinjection of glutamate antagonist receptors, kynurenic acid (5.0 mM, 100nl) into the ipsilateral RVLM reversibly attenuated glutamate-induced bradycardi and depressor responses to BST stimulation in OVX only animals (OVX; n=8 AP,-13.7±2.6 and HR,-8.1±4.3) but in OVX+E animals only attenuated glutamate induced bradycardia, but not depressor response (OVX+E;n=7 AP,-11.7±3.8 and HR, -16.7±2.3). These data suggest that RVLM sympathetic premotor neurons contain glutaminergic receptors mediate the sympathoinhibitory responses to stimulation of BST in OVX animals.

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منابع مشابه

Glutaminergic receptor in the rostroal ventrolateral medulla mediate the cardiovascular responses to activation of the bed nucleus of the stria terminalis in female ovariectomized rat

Introduction: Experiments were done to investigate the cardiovascular response to glutamate (Glu) injection in the bed nucleus of stria terminalis (BST) in urethane anesthetized ovariectomized (OVX) or OVX estrogen  treated (OVX+E)  female Wistar rats. In this study also the effect of glutaminergic system of the rostral ventrolateral medulla (RVLM) on Glu stimulation of cardiovascular...

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GABAergic receptors in rostral ventrolateral medulla mediates the cardiovascular responses to activation of bed nucleus of the stria terminalis in the female rat

The bed nucleus of the stria terminalis (BST) is known to contain estrogen (E)- concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of GABA-A antagonist receptors, bicuculline methiodide (BMI), in the rostral ven...

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Effect of GABAA Receptors in the Rostral Ventrolateral Medulla on Cardiovascular Response to the Activation of the Bed Nucleus of the Stria Terminalis in Female Ovariectomized Rats

Background: The areas of the bed nucleus of the stria terminalis (BST) with a high density of estrogen receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (RVLM). We aimed to find the contribution of the RVLM to cardiovascular responses elicited by glutamate microinjection into the BST. Methods: Experiments were done in α-ch...

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GABAergic receptors in rostral ventrolateral medulla mediates the cardiovascular responses to activation of bed nucleus of the stria terminalis in the female rat

The bed nucleus of the stria terminalis (BST) is known to contain estrogen (E)- concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of GABA-A antagonist receptors, bicuculline methiodide (BMI), in the rostral ven...

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effect of gabaa receptors in the rostral ventrolateral medulla on cardiovascular response to the activation of the bed nucleus of the stria terminalis in female ovariectomized rats

background: the areas of the bed nucleus of the stria terminalis (bst) with a high density of estrogen receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (rvlm). we aimed to find the contribution of the rvlm to cardiovascular responses elicited by glutamate microinjection into the bst. methods: experiments were done in α-chloralose...

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عنوان ژورنال

دوره Volume 3  شماره Supplement 1

صفحات  94- 94

تاریخ انتشار 2010-11-20

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